We have done a lot of systems biology research in the academic environment.

Selected papers to read

2019 | Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

M.P. Menden et al.(K.-H.Cho, S.Cho, Y.Han, J.Kim, Y.Kim, Je-Hoon Song as members of AstraZeneca-Sanger Drug Combination DREAM Consortium)

2018 | A positive feedback loop bi-stably activates fibroblasts

So-Young Yeo, Keun-Woo Lee, Dongkwan Shin, Sugyun An, Kwang-Hyun Cho & Seok-Hyung Kim

2017 | Percolation transition of cooperative mutational effects in colorectal tumorigenesis

Dongkwan Shin, Jonghoon Lee, Jeong-Ryeol Gong & Kwang-Hyun Cho

2017 | Protein disulfide isomerase inhibition synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma

Jae-Kyung Won, Su Jong Yu, Chae Young Hwang, Sung-Hwan Cho, Sang-Min Park, Kwangsoo Kim, Won-Mook Choi, Hyeki Cho, Eun Ju Cho, Jeong-Hoon Lee, Kyung Bun Lee, Yoon Jun Kim, Kyung-Suk Suh, Ja-June Jang, Chung Yong Kim, Jung-Hwan Yoon, Kwang-Hyun Cho

2016 | Toward Community Standards and Software for Whole-Cell Modeling

Dagmar Waltemath, Jonathan R Karr, Frank T Bergmann, Vijayalakshmi Chelliah, ..., Je-Hoon Song, ..., Falk Schreiber

2015 | Silence on the relevant literature and errors in implementation

Philippe Bastiaens, Marc R Birtwistle, Nils Blüthgen, Frank J Bruggeman, Kwang-Hyun Cho, Carlo Cosentino, Alberto de la Fuente, Jan B Hoek, Anatoly Kiyatkin, Steffen Klamt, Walter Kolch, Stefan Legewie, Pedro Mendes, Takashi Naka, Tapesh Santra, Eduardo Sontag, Hans V Westerhoff & Boris N Kholodenko

2014 | MLK3 Is Part of a Feedback Mechanism That Regulates Different Cellular Responses to Reactive Oxygen Species

Ho-Sung Lee, Chae Young Hwang, Sung-Young Shin, Ki-Sun Kwon, Kwang-Hyun Cho

2014 | The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts

Je-Hoon Song, David J. Huels, Rachel A. Ridgway, Owen J. Sansom, Boris N. Kholodenko, Walter Kolch, and Kwang-Hyun Cho

2014 | The switching role of b-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes

Sung-Young Shin, Taeyong Kim, Ho-Sung Lee, Jun Hyuk Kang,, Ji Young Lee, Kwang-Hyun Cho, & Do Han Kim

2012 | The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor

Jae-Kyung Won, Hee Won Yang, Sung-Young Shin, Jong Hoon Lee, Won Do Heo, and Kwang-Hyun Cho

2012 | Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage

Minsoo Choi, Jue Shi, Sung Hoon Jung, Xi Chen and Kwang-Hyun Cho

2011 | Reduction of Complex Signaling Networks to a Representative Kernel

Jeong-Rae Kim, Junil Kim, Yung-Keun Kwon, Hwang-Yeol Lee, Pat Heslop-Harrison, Kwang-Hyun Cho

2020 | Ultraprecise single-molecule localization microscopy enables in situ distance measurements in intact cells

Simao Coelho, Jongho Baek, Matthew S. Graus, James M. Halstead, Philip R. Nicovich, Kristen Feher, Hetvi Gandhi, J. Justin Gooding, Katharina Gaus

Spinout from 20+ years of research experiences

We provide innovative drug discovery research services, specializing in systems biology and AI technology.